For an oocyte for being Prepared for fertilization and expansion into an embryo, the best set of genes should be turned on. Namekawa suspected that this pre-programming from the oocyte genome comes about in numerous stages — the main 1 beginning throughout the time a feminine is born. He thought that chromatin remodeling proteins did Considerably of this operate, by shifting spools all around.
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“The Business of chromatin influences which genes could be expressed,” states Namekawa. That’s since the precise spots of the spools, plus the spacing in between them, decides which stretches of DNA is usually accessed by molecules termed transcription elements, which latch on to genes and switch them on.
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